Web app based on .net - best practice?

Imagine I have a .net based application

I thought it would be a good idea to have the presentation layer (asp) in a DMZ and the business layer (components in VB and C#) in a safe site behind a firewall. The communication in between would take place with RPC calls.
I know that RPC is not considered secure but we have a firewall in between the DMZ and the safe site (not a guarantee things work out, I know)

I wondered what Microsoft says about the division of the layers, is there a recommendation or some kind of best practice for something like this?

Do any know of pointers to information about this?

My concern is that if the whole application was based in the DMZ, it would be hard to control injections and stuff like that. With the division we can control (somewhat) what calls goes to the safe site (business layer).

I would love to hear opinions on this matter

Thanks,

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